The robbery happened around midnight at the Quick Check on US 52 South at West Main Street. Police say the suspect entered the store pointing a gun and demanding money.
The man reportedly took money from the clerk and took off on foot toward Broome Street.
The suspect is described as a white man wearing a black hooded jacket, tan or greenish gloves, blue jeans and white sneakers.
Police say no one was injured during the robbery.
Anyone with information is asked to call Albemarle Police Department at 704-984-9500.